Obesity’s Link to Early Alzheimer’s Indicators #

In recent studies, a correlation has been identified between increasing belly size and shrinking brain memory centers, with the appearance of beta amyloid and tau as early as age 40 to 50. These indicators often precede cognitive symptoms of Alzheimer’s by decades. Beta amyloid plaques and tau tangles are considered precursors to potential Alzheimer’s diagnosis, with plaques appearing first followed by tau tangles.

“The more amyloid or tau you have in the brain, the sicker the brain becomes.” Lower blood flow is a marker for a declining brain, leading to the atrophy of gray matter in the hippocampus, a crucial part of the brain’s memory center.

Obesity poses a significant challenge globally, with projections estimating that over half the global population could be overweight or obese within a decade. In the United States alone, the number of overweight or obese individuals could reach 260 million by 2050. Obesity is identified as a risk factor for dementia, potentially accounting for over 2 million cases attributable to obesity.

A pilot study indicated that visceral fat, a type of deep abdominal fat, correlates with inflammation and amyloid buildup in the brains of individuals aged 40 to 50. Visceral fat, as opposed to subcutaneous fat, wraps around major organs and constitutes a mere 10% of total body fat. Specialized imaging techniques are used to measure this type of fat, revealing that higher levels are associated with increased inflammation and insulin resistance, both of which are potential accelerants for metabolic abnormalities and Alzheimer’s disease markers.

The study also found a link between deep belly fat and brain atrophy in the hippocampus, highlighting Alzheimer’s biomarkers. PET scans revealed that increased visceral fat levels corresponded with elevated amyloid and tau levels.

“This work is highly impactful and clinically relevant for the millions with early signs of Alzheimer’s starting silently in their brains.” There are proactive ways to reduce belly fat, such as focusing on body composition rather than weight and incorporating exercise like brisk walking. Engaging in ‘Zone 2 training’ — a conversational level of exertion — and building muscle mass can aid in fat reduction. Strength training and adequate protein intake are also recommended strategies for maintaining muscle mass and boosting metabolism.